2024 Tog domain

Tog domain

Author: gsde

August undefined, 2024

WebTOG. SMART accession number: SM01349. Description: XMAP215/Dis1 proteins, such as Alp14 and XMAP215, increase microtubules dynamic polymerization rates by recruiting … WebAug 16, 2024 · N-terminal region of Cls1p indeed contains two active Tumor Overexpressed Gene (TOG) domains that are similar to XMAP215 TOG domains. A Cls1p dimer binds a single αβ-tubulin heterodimer through two sets of TOG domains, and to the MT lattice through a serine arginine-rich domain. Despite this similarity, Cls1p behaves very …

An isolated CLASP TOG domain suppresses microtubule catastrophe …

WebMay 24, 2024 · TOG-domain proteins Curr Biol. 2024 May 24;31(10):R499-R501. doi: 10.1016/j.cub.2024.01.039. Authors Veronica J Farmer 1 , Marija Zanic 2 Affiliations 1 … WebJul 17, 2015 · To investigate the effects of each TOG domain on CLASP-mediated MT dynamics, we determined the crystal structures of the two TOG domains (TOG2 and TOG3) of CLASP2. We found that these TOGs have arched structures but assume the different orientation of the curvature from that of the canonical TOG domain, Stu2-TOG1. top hat auto trading for ninja 8

The N-terminal TOG domain of Arabidopsis MOR1 modulates …

WebAug 17, 2012 · The ability to function as a catalyst for microtubule elongation suggests that XMAP215/Stu2p family proteins use their tubulin-binding TOG domains to distinguish between at least three different forms of αβ-tubulin: unpolymerized, in the body of the microtubule, and at the growing end of the microtubule. WebMay 31, 2024 · Microtubules are heavily regulated dynamic polymers of αβ-tubulin that are required for proper chromosome segregation and organization of the cytoplasm. Polymerases in the XMAP215 family use arrayed TOG domains to promote faster microtubule elongation. Regulatory factors in the cytoplasmic linker associated protein … WebJan 18, 2024 · Identification of a TOG domain–containing protein required for full flagellar length. During the course of screening mutants obtained from the Chlamydomonas Library Project (CLiP) (Li et al., 2024), we found a mutant strain with shorter flagella than that of wild-type (WT) cells that we provisionally refer to as shf-A ().Flagella in these mutant … pictures of body wave

Structures of TOG1 and TOG2 from the human microtubule …

A cryptic tubulin-binding domain links MEKK1 to microtubule

WebNov 11, 2015 · A TOG domain consists of six pairs of antiparallel α-helices, termed HEAT repeats (HRs), which form an oblong, solenoid-like structure. TOG domains bind tubulin … WebThe Open Group Architecture Framework (TOGAF) is the most used framework for enterprise architecture as of 2024 that provides an approach for designing, planning, … pictures of body typesWebTOGARAM1/Crescerin is a TOG (tumor overexpressed gene) domain array-containing protein that regulates cilia microtubule structure. TOG domains bind tubulin and have … pictures of boelies

"WebFeb 16, 2024 · By searching databases for TOG domain array-containing proteins, Das et al. (2015) identified human and mouse TOGARAM1, which they called Crescerin-1 after the Latin 'crescere' (grow). Human and mouse Crescerin-1 contain 1,773 and 1,776 amino acids, respectively. Both have an N-terminal pair of TOG domains and a C-terminal pair of … " - Tog domain

Tog domain

WebTOG-domain proteins Veronica J. Farmer1 and Marija Zanic1,2,* What are TOG-domain proteins? TOG-domain proteins are a class of proteins that contain at least one tumor … WebAug 17, 2024 · The canonical function of TOG domains is the regulation of microtubule dynamics through conformation-specific binding to tubulin (30–33). MEKK1 only contains one TOG domain, and, while TOG domains often occur in arrays, recent work has shown that even isolated TOG domains can modulate microtubule dynamics (34, 35).

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WebJul 17, 2015 · To investigate the effects of each TOG domain on CLASP-mediated MT dynamics, we determined the crystal structures of the two TOG domains (TOG2 and …

WebThe molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the dynamic properties of microtubules (MTs) are still poorly understood. We review recent … WebJul 19, 2024 · Tubulin-binding TOG domains are found arrayed in a number of proteins that regulate microtubule dynamics. While much is known about the structure and function of …

WebJul 2, 2024 · Mammalian CLASPs encompass three TOG-like domains, TOG1, TOG2, and TOG3, none of which bind to free tubulin. TOG2 is essential for catastrophe suppression, … WebNov 26, 2024 · The x-ray crystal structures of human CLASP1 TOG1 and TOG2 are presented to highlight the structural diversity of TOG domains within the CLASp TOG array and provide a molecular foundation for understandingCLASP-dependent effects on microtubule dynamics. Tubulin-binding TOG domains are found arrayed in a number of …

WebNov 13, 2024 · TOG1 and TOG2 domains were identified after cycles of density modification as described above. Four αβ-tubulins, four TOG domains, and two DRPΔN models were …

WebThe TOG domain face composed of intra-HEAT loops forms a contiguous, conserved tubulin-binding surface. Nested within the conserved intra-HEAT loop 1 is an invariant, … pictures of boeing planesWebThe TOG domain arrays in XMAP215 family of proteins bind to free tubulin dimers, and promote their stable incorporation onto MT plus-ends while the basic linker regions separating the TOG domains ... top hat bakeryWebJan 31, 2011 · Members of the XMAP215/Dis1 family are characterized by a varying number of TOG domains at their N termini ().Based on mutants in TOG domains that interfere … top hat balloon werksWebMar 1, 2007 · In Figure 3 is an alignment of TOG-domain sequences from X. laevis XMAP215 (five TOG domains), C. elegans Zyg9 (three TOG domains), and budding … top hat backgroundWebJul 19, 2024 · Tubulin-binding TOG domains are found arrayed in a number of proteins that regulate microtubule dynamics. While much is known about the structure and function of … top hat bakery menuWebJun 4, 2013 · The TOG domain face composed of intra-HEAT loops forms a contiguous, conserved tubulin-binding surface. Nested within the conserved intra-HEAT loop 1 is an invariant, signature, ... pictures of boerewors rollsWebIn strains with targeted mutations of Che12 TOG domains, mutant Che12 properly localized to cilia, but the mutants otherwise phenocopied the Che12 deletion strain. Das et al. (2015) concluded that the TOG domain tubulin-binding activity of Che12 is required for proper sensory cilia development and cilia-based chemotactic function in C. elegans. pictures of boeing 737 800