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Scd1 human

WebJan 1, 2011 · In humans, SCD1 expression was found to be elevated in skeletal muscle after endurance exercise, which prevented fatty acid-induced insulin resistance . This effect was attributed to the enhanced lipogenic capacity that partitions FFA and their bioactive metabolites into neutralized lipids such as TG, thus reducing the proinflammatory … WebJan 14, 1999 · Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2.

SCD1 deficiency exacerbates osteoarthritis by inducing …

WebValidated for WB, IP, IHC, IF. Highly specific and rigorously validated in-house, SCD1 (C12H5) Rabbit Monoclonal Antibody (CST #2794) ... Human, Mouse. Source / Purification. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu35 of mouse SCD1. WebImmunohistochemical analysis of paraffin-embedded human adipose tissue within cardiac muscle tissue labeling SCD1 with ab236868 at 1/2000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) ready to use. Positive staining in human adipose cells in cardiac muscle (PMID: 15907797) is observed. Counter stained with hematoxylin. nancy drew curse of blackmoor manor trailer https://round1creative.com

Human SCD (SCD1) knockout HeLa cell line (ab265220)

Stearoyl-CoA desaturase (SCD; EC 1.14.19.1) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity an… WebMar 21, 2024 · SCD (Stearoyl-CoA Desaturase) is a Protein Coding gene. Diseases associated with SCD include Non-Alcoholic Fatty Liver Disease and Abdominal Obesity … WebHere we report the 3.25-Å crystal structure of human SCD1 in complex with its substrate, stearoyl-coenzyme A, which defines the new SCD1 dimetal catalytic center and reveals … megaphone brands activism

SCD Gene - GeneCards SCD Protein SCD Antibody

Category:6319 - Gene ResultSCD stearoyl-CoA desaturase [ (human)]

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Scd1 human

Stearoyl CoA Desaturase 1: Role in Cellular Inflammation and Stress

WebApr 18, 2024 · Cells with overexpressed SCD1 were resistant to Gefitinib. a, b The expression of SCD1 in five lung cancer cell lines A549, H838, H1573 and one normal human bronchial epithelial cells BEAS-2B was analyzed.c, d The cell vitality of A549 and H1573 with or without SCD1 overexpression was assessed after treatment with different doses of Gefitinib (0, 5, … WebFeb 28, 2024 · As SCD1 is an important rate-limiting enzyme in the anabolic process of MUFAs, the effect of SCD1 alterations in human OA articular cartilage was examined. When the cartilage specimens were stained with Safranin O/fast green and hematoxylin and eosin (HE) to determine the degree of deterioration, we found the superficial portion of normal …

Scd1 human

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WebMar 27, 2024 · In human HCC tissues, collagen content, a marker of increasing matrix stiffness, and increased expression of SCD1 together predicted poor survival of HCC patients. An SCD1-dependent mechanoresponsive pathway that responds to increasing matrix stiffness in the tumor microenvironment promotes HCC invasion and metastasis … WebAug 24, 2024 · Two SCD isoforms have been identified in human tissues: SCD1 and SCD5 [52–54]. SCD1 is the main isoform, ubiquitously expressed, with a prevalence in adipose tissue, heart, brain, liver and lungs. SCD5 is poorly expressed in adult human tissues and is mostly restricted to the brain and pancreas.

WebMar 28, 2015 · Furthermore, the human HCC cells death triggered by inhibition of SCD1 was partly involved in autophagy-induced apoptosis via AMPK signaling. Our findings reveal a … WebJun 6, 2002 · Function. Stearoyl-CoA desaturase that utilizes O 2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates …

WebFour SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 … WebSCD1 is known to undergo post-translational modifications and the sizes differ in different cell lines so the observed band size can be different than predicted band size. As positive control we recommend using SCD1 over-expressed 293 transfected cell lysates for western blot. This product was changed from ascites to tissue culture supernatant ...

Web(Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 …

WebNov 16, 2024 · It turns long chain saturated fats into long chain monounsaturated fats. Insulin is an up-regulator of SCD1 and leptin down-regulates it. Insulin pushes your body … nancy drew curse of blackmoor walkthroughWebSCD1 / SCD ELISA Kit LS-F32424 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative detection of Human SCD1 / SCD in Plasma, Serum, Tissue Homogenates. It is … nancy drew curse of blackmoor manor uhsWebJan 27, 2016 · Alteration of SCD1 expression and ceramide signals in human colorectal tumor samples. The levels of (a) SCD 1 mRNA expression, (b) SCD1 protein expression, density quantification by western-blot ... megaphone buck sextonWebJun 22, 2015 · The residues on SCD1 that form contacts with the stearoyl-CoA are also conserved in other isoforms in humans (hSCD5) and in the mouse SCD (Supplementary … megaphone boulangerWebApr 11, 2024 · MiR-3180 negatively correlated with CD36 and SCD1 expression and predicted clinical outcomes in HCC patients. Using genome-wide CRISPR/Cas9-knockout library screening, we found that miR-3180 knockout greatly enhanced lipid content in HCC cells [].We further detected miR-3180-regulated genes involved in lipid metabolism … megaphone bottom patternWebstearoyl-CoA desaturase 1 inhibition induces CHOP-dependent cell death in human cancer cells. Oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of … megaphone bostonWebHuman SCD-1 is a 4-transmembrane (TM), 359 amino acid (aa) protein. It contains a 71 aa cytoplasmic N-terminus, followed by two TM segments (aa 72-119) and an extended … nancy drew cw characters