Webb6 apr. 2024 · SASH1 contains two predicted nuclear localization signals (NLS1 and NLS2), the conserved Src-homology 3 domain (SH3) and the two sterile alpha-motifs (SAM1 and SAM2). Amino acid residues of the SASH1 coding sequence are indicated. Four deleted SASH1 fragments were cloned to pEGFP-C3 vector and expressed as GFP-deleted … Webb26 sep. 2012 · SASH1 antibody was purchased from Bethyl laboratories Inc. (Montgomery, MA, USA) and the primary GAPDH antibody was purchased from Proteintech Group (Chicago, IL, USA). Cell proliferation assay Proliferation assay was carried out to assess cell viability in the A-375 (SASH1), A-375 (EGFP) and A-375 cell lines.
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Webb28 maj 2024 · SASH1 protein expression was almost 2.5-fold higher in astrocytes than in C6 glioma cells. After the astrocytes were treated with SASH1 siRNA for 3 days, the SASH1 mRNA and protein levels... WebbSASH1 (Q18037095) From Wikidata. Jump to navigation Jump to search. protein-coding gene in the species Homo sapiens ... king family eye care
SASH1 Suppresses the Proliferation and Invasion of Human Skin …
Webb1 dec. 2024 · SAM diversity: SASH1-SAM1 is different from SASH3-SAM, a potential contributing factor for the diverse functions between SASH1 and SASH3. • Mutagenesis identified a way to shift between monomer and oligomer status of SAM1, providing a basis to target SAM1 for therapeutic strategy. • Webb17 mars 2016 · SAM- and SH3-domain containing 1 (SASH1) is a recently identified tumor suppressor gene that is required in the tumorigenesis of breast and other solid carcinomas. The SASH1 protein contains SH3 and SAM domains, indicating that it may serve an important role in intracellular signal transduction. The purpose of the present study was … Webb26 mars 2024 · These domains are predominantly found in signaling molecules, adaptors, and scaffold proteins. SASH1 also has an N-terminal 25-residue proline-rich sequence. … king family eye care rocky hill ct