site stats

Klf6 and t cell activation

WebFeb 3, 2016 · Here, we identify Kruppel-like transcription factor-6 (KLF6) as a critical regulator of pathogenic myeloid cell activation in human and experimental IBD. We found … WebNov 22, 2024 · The presumed role of KLF6 as tumor suppressor comes from its ability to reduce cell proliferation through different cellular mechanisms as the regulation of cell …

The Adapter Molecule Sin Regulates T-Cell-Receptor-Mediated …

WebKLF6 (Kruppel-like factor 6) is a zinc finger transcription factor and a tumor suppressor that is frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces apoptosis in cancer cells through mechanisms still not defined. Here we show that KLF6 induces apoptosis in prostate cancer cells by ATF3 (activating transcription factor 3) … WebMar 29, 2024 · Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the VHL tumor suppressor gene and mTOR signalling pathway hyperactivation. The pro-angiogenic factor PDGFB, a transcriptional target of super enhancer-driven KLF6, can activate the mTORC1 signalling pathway in … thissuper https://round1creative.com

Single-cell transcriptomics of human T cells reveals tissue and ...

WebAug 1, 2004 · KLF6 induced a dose-dependent increase in IGF-IR promoter activity, with maximal stimulation occurring with 0.1 μg expression vector (337 ± 32% activation). Remarkably, KLF6 displayed a very potent activity even at input doses as low as 10 ng DNA (260 ± 23% stimulation). WebMoreover, KLF6 strongly associated with T-cell activation in psoriasis [ 27 ], and KLF6 knockout mice showed a protected effect to against chemically induced colitis, … WebNov 22, 2024 · The presumed role of KLF6 as tumor suppressor comes from its ability to reduce cell proliferation through different cellular mechanisms as the regulation of cell cycle components, oncogene signaling and apoptosis ( Ito et al., 2004; Kimmelman et al., 2004; Narla et al., 2007 ). this sunglasses or these sunglasses

Evaluating the transcriptional landscape and cell-cell …

Category:Calcium Carbonate based Nanoparticles to Activate T cells for …

Tags:Klf6 and t cell activation

Klf6 and t cell activation

KLF6 protein expression summary - The Human Protein Atlas

WebNov 23, 2013 · This study has identified two new genes, SPATS2L and KLF6, strongly associated with T cell activation in psoriasis. Functional analyses of the gene expression … WebMar 21, 2024 · GeneCards Summary for KLF6 Gene. KLF6 (KLF Transcription Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer . Among its related pathways are Aryl hydrocarbon receptor pathway and Adipogenesis . An important paralog of this gene is KLF7.

Klf6 and t cell activation

Did you know?

WebKlf6: 5.25E-05: 0.09565782: 0.60671325: 0.15002368: Open in a separate window. ... state through LIF signalling which activates the STAT3 cascade to retain undifferentiated self-renewal and regulate cell survival, through activation of PKB/AKT signalling [31, 32]. We analysed activation of AKT (phosphorylation at ser493) ... WebKLF6 - Function 1 GENE 3 ISO 53 REF Gold Only Extend overview KLF6 → Krueppel-like factor 6 Protein also known as : Suppressor of tumorigenicity 12 protein . Gene name : KLF6 Family name : Krueppel C2H2-type zinc-finger protein Entry whose protein (s) existence is based on evidence at protein level. Show evidences

WebApr 11, 2024 · The DEGs in 340 the CD4+CD8+ population suggest an imbalance in immune regulation following irradiation. 341 Increases in KLF2 in IR PGs may represent a shift in T-cell populations as KLF2 is highly 342 Jo urn al Pre- pro f Page 16 expressed in naïve and memory T-cells and downregulated by TCR activation and cytokine 343 stimulation in ... WebApr 12, 2024 · Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.

WebOct 17, 2024 · nduction of NME1 and IFIT3 expression during T cell activation. a Expression of NME1 and IL2RA mRNA by blood CD4 + or CD8 + T cells after stimulation with anti-CD3/anti-CD28 antibodies by qPCR. WebDec 19, 2013 · Krüppel-like factor 6 (KLF6, Zf9, COPEB) belongs to the family of Sp1-like/KLF transcription factors that contain three highly conserved Cys2-His2 type zinc fingers located in the C-terminus and a proline and serine rich NH 2 terminal activation domain [].The KLF6 gene is located on chromosome arm 10p and has four exons separated by three introns …

WebApr 14, 2024 · Previous studies have shown that KLF6 directly transactivates the P21 promoter in an immortalized human embryonal fibroblast cell line (293 T) and that the binding sites for KLF6 have been ...

WebNov 25, 2010 · KLF6 has been shown to regulate the expression of multiple genes and is associated with wound healing and suppression of tumorigenesis. 55 KLF6 was found to induce iNOS promoter activity in Jurkat T cells, primary T lymphocytes, and COS-7 cells … this super final static keyword in javaWebc-Jun jest protein koji je kod ljudi kodiran genom JUN sa hromosoma 1. c-Jun, u kombinaciji sa c-Fos, formira AP-1 transkripcijski faktor za rani odgovor, Prvo je identificiran kao Fos-vezujući protein p39 i tek kasnije ponovo otkriven kao proizvod gena JUN. c-jun je bio prvootkriveni onkogeni transkripcijski faktor. The proto-oncogene c-Jun je ćelijski … this supplies current to the circuit miladyWebKLF6 INFORMATION. Proteini. Full gene name according to HGNC. Kruppel like factor 6. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. KLF6 (BCD1, COPEB, CPBP, GBF, PAC1, ST12, Zf9) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). this supersedes the previous memoWebApr 4, 2024 · KLF6 acts as a tumor suppressor in CMM cells and miR-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR inactivation and p21 … this super的区别WebUnlike wild-type KLF6, the cancer-derived KLF6 mutant cannot induce the expression of p21 WAF1, which promotes the cell cycle from G1 to the S phase, and ultimately loses the inhibitory function of cell proliferation [139]. Moreover, KLF7 has been reported to stimulate the overexpression of vacuolar protein sorting 35 (VPS35), a protein that is ... this supersedesWebSep 1, 2010 · IκBζ has been shown to regulate IL-6 production in macrophages and Th17 development in T cells. However, the role of IκBζ in natural killer (NK) cells has not be understood. In the present study, we found that the expression of IκBζ was rapidly induced in response to IL-18 in NK cells, but not in T cells. thissupportWebApr 21, 2024 · Despite the great success of these therapies, many patients still have a low response rate to CAR T cell therapy due to insufficient T cell priming or activation, resulting in T cell exhaustion and functional impairment. The combination of Ionomycin (ION) and phorbol 12-myristate 13-acetate (PMA) is commonly used to activate T cells. this support